Pathology and Cell Biology
USF Health - College of Medicine
Login here to update your profile  
My Profile

Marzenna Wiranowska , Ph.D.

Primary Department: COLLEGE OF MEDICINE PATHOLOGY & CELL BIOLOGY

Associate Professor
COLLEGE OF MEDICINE PATHOLOGY & CELL BIOLOGY
profile Image
Contacts
Email: mwiranow@health.usf.edu
Phone: (813) 974-3289
Office: MDC, 2108
Mailing address 12901 Bruce B. Downs Blvd. ,MDC 11
Tampa, FL 33612
View My C.V.
 
Education
  • PHD, Virology-Immunology, Polish Academy Of Sciences , Wroclaw, Poland - 1980.
    		•
  • M.S., Microbiology-Immunology, Medical Academy of Warsaw , Warsaw, Poland - 1974.
    		•
  • B.S., Biology, Warsaw University , Warsaw, Poland - 1972.
    		•
     
    Interdisciplinary & Emerging Signature Programs
    Cancer Biology, Neuroscience.
     
    Research Summary

    In my current research I am focusing on the biology and treatment of glioma using in vitro and in vivo models. Specific areas of research include: 1) studies of the extracellular matrix in the brain and its role in glioma invasion; 2) evaluation of the cellular entry and cellular localization of chlorotoxin, a scorpion derived 36 amino acid peptide designated as TM601 in glioma and other tumor cells.(TM601 was tested in Phase II clinical trials in adult recurrent glioma and in Phase I in various other tumors);and 3) evaluation of thermo-responsive double packaged system for localized delivery of therapeutics to glioma and other tumors such as ovarian carcinoma.

     


    Selected Publications
  • Szmigielski, S.Luczak, M.Wiranowska, M. Karyometric observations of WISH cell cultures irradiated with 3 GHz microwaves. Folia Histochemica et Cytochemica. 13(3-4): 151-9, 1975.
  • Szmigielski, S.Luczak, M.Wiranowska, M. Effect of microwaves (3GHz) on cell function and virus replication in cell cultures irradiated in vitro. Annals of the New York Academy of Sciences. 247(): 263-74, 1975.
  • Szmigielski, S.Jeljaszewicz, J.Wiranowska, M. Acute staphylococcal infections in rabbits irradiated with 3-GHz microwaves. Annals of the New York Academy of Sciences. 247(): 305-11, 1975.
  • Lin, L.S., Wiranowska-Stewart, M., Chudzio, T., and Stewart II, W.E. Characterization of the molecular heterogeneities of human interferons: Differences in the cross-species antiviral activities of various molecular populations in human leukocyte interferons The Journal of General Virology. 39(): 259-264, 1977.
  • Stewart II, W.E., Wiranowska-Stewart, M., and LeGoff, S. Characterization of the distinct molecular populations of Type I mouse interferons The Journal of General Virology. 37(): 277-284, 1977.
  • Wiranowska-Stewart, M. and Stewart II, W.E. The role of chromosome 21 in sensitivity to human interferons The Journal of General Virology. 37(): 629-633, 1977.
  • Stewart II, WE.Lin, L.Chudzio, T.Wiranowska-Stewart, M. Molecular alterations of interferons. Texas Reports on Biology and Medicine. 35(): 193-7, 1977.
  • Wiranowska-Stewart, M.Chudzio, T.Stewart II, WE. Repeated 'superinduction' of interferon in human diploid fibroblast cultures. The Journal of General Virology. 37(1): 221-3, 1977.
  • Stewart II, WE.Lin, LS.Wiranowska-Stewart, M.Cantell, K. Elimination of size and charge heterogeneities of human leukocyte interferons by chemical cleavage. Proceedings of the National Academy of Sciences of the United States of America. 74(10): 4200-4, 1977.
  • Stewart II, WE.Chudzio, T.Lin, LS.Wiranowska-Stewart, M. Interferoids: in vitro and in vivo conversion of native interferons to lower molecular weight forms. Proceedings of the National Academy of Sciences of the United States of America. 75(10): 4814-8, 1978.
  • Lin, LS.Wiranowska-Stewart, M.Chudzio, T.Stewart II, WE. Characterization of the size and charge heterogeneities of human leukocyte interferon populations. Archives of Virology. 56(3): 269-72, 1978.
  • Lin, LS.Wiranowska-Stewart, M.Chudzio, T.Stewart II, WE. Characterization of the heterogeneous molecules of human interferons: differences in the cross-species antiviral activities of various molecular populations in human leukocyte interferons. The Journal of General Virology. 39(1): 125-30, 1978.
  • Stewart II, WE.Wiranowska-Stewart, M.Koistinen, V.Cantell, K. Effect of glycosylation inhibitors on the production and properties of human leukocyte interferon. Virology. 97(2): 473-6, 1979.
  • Hanley, DF.Wiranowska-Stewart, M.Stewart II, WE. Pharmacology of interferons I. Pharmacologic distinctions between human leukocyte and fibroblast interferons. International Journal of Immunopharmacology. 1(3): 219-26, 1979.
  • Wiranowska-Stewart, M.Lin, LS.Braude, IA. Stewart II, WE. Production, partial purification and characterization of human and murine interferons--type II. Molecular Immunology. 17(5): 625-33, 1980.
  • Wiranowska-Stewart, M. Heterogeneity of human gamma interferon preparations: evidence for presence of alpha interferon. Journal of Interferon Research. 1(2): 315-21, 1981.
  • von Wussow, P.Platsoucas, CD.Wiranowska-Stewart, M.Stewart II, WE. Human gamma interferon production by leukocytes induced with monoclonal antibodies recognizing T cells. Journal of Immunology. 127(3): 1197-200, 1981.
  • Wiranowska-Stewart, M.Stewart II, WE. Determination of human leukocyte populations involved in production of interferons alpha and gamma. Journal of Interferon Research. 1(2): 233-44, 1981.
  • von Wussow, P.Chen, YS.Wiranowska-Stewart, M.Stewart II, WE. Induction of human gamma-interferon in lymphoid cells by Staphylococcus enterotoxin B; partial purification. Journal of Interferon Research. 2(1): 11-20, 1982.
  • Wiranowska-Stewart, M.Hadden, JW. Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production. International Journal of Immunopharmacology. 8(1): 63-9, 1986.
  • Zheng, QY.Wiranowska, M.Sadlik, JR.Hadden, JW. Purified podophyllotoxin (CPH-86) inhibits lymphocyte proliferation but augments macrophage proliferation. International Journal of Immunopharmacology. 9(5): 539-49, 1987.
  • Wiranowska, M.Kaido, T.Caspritz, G.Cook, J.Hadden, J. Interleukin-2 and coculture with thymic epithelial cells synergistically induce prothymocyte differentiation and proliferation. Thymus. 10(3-4): 231-45, 1987.
  • Wiranowska, M.Wilson, TC.Bencze, KS.Prockop, LD. A mouse model for the study of blood-brain barrier permeability. Journal of Neuroscience Methods. 26(2): 105-9, 1988.
  • Wiranowska, M.Wilson, TC.Thompson, K.Prockop, LD. Cerebral interferon entry in mice after osmotic alteration of blood-brain barrier. Journal of Interferon Research. 9(3): 353-62, 1989.
  • Wiranowska, M.Gonzalvo, AA.Saporta, S.Gonzalez, OR.Prockop, LD. Evaluation of blood-brain barrier permeability and the effect of interferon in mouse glioma model. Journal of Neuro-Oncology. 14(3): 225-36, 1992.
  • Wiranowska, M. Blood-brain barrier and treatment of central nervous system tumors. The Journal of the Florida Medical Association. 79(10): 707-10, 1992.
  • Naidu, AK.Wiranowska, M.Kori, SH.Roetzheim, KC.Kulkarni, AP. Inhibition of cell proliferation and glutathione S-transferase by ascorbyl esters and interferon in mouse glioma. Journal of Neuro-Oncology. 16(1): 1-10, 1993.
  • Naidu, AK.Wiranowska, M.Kori, SH.Prockop, LD.Kulkarni, AP. Inhibition of human glioma cell proliferation and glutathione S-transferase by ascorbyl esters and interferon. Anticancer Research. 13(5A): 1469-75, 1993.
  • Wiranowska, M.Naidu, AK. Interferon effect on glycosaminoglycans in mouse glioma in vitro. Journal of Neuro-Oncology. 18(1): 9-17, 1994.
  • Wiranowska, M.Prockop, LD.Naidu, AK.Saporta, S.Kori, S.Kulkarni, AP. Interferon entry through the blood-brain barrier in glioma and its effect on lipoxygenase activity. Anticancer Research. 14(3A): 1121-6, 1994.
  • Naidu, KA.Wiranowska, M.Phuphanich, S.Prockop, LD. Modulation of glioma cell growth and 5-lipoxygenase expression by interferon. Anticancer Research. 16(6B): 3475-82, 1996.
  • Menzies, R., Phelps, C.Wiranowska, M.Oliver, J.Chen, L.Horvath, E.Hall, N. The effect of interferon-alpha on the pituitary-adrenal axis. Journal of Interferon & Cytokine Research. 16(8): 619-29, 1996.
  • Wiranowska, M.Tresser, N.Saporta, S. The effect of interferon and anti-CD44 antibody on mouse glioma invasiveness in vitro. Anticancer Research. 18(5A): 3331-8, 1998.
  • Wiranowska, M.Ransohoff, J.Weingart, JD.Phelps, C.Phuphanich, S.Brem, H. Interferon-containing controlled-release polymers for localized cerebral immunotherapy. Journal of Interferon & Cytokine Research. 18(6): 377-85, 1998.
  • Wiranowska, M.Rojiani, AM.Gottschall, PE.Moscinski, LC.Johnson, J.Saporta, S. CD44 expression and MMP-2 secretion by mouse glioma cells: effect of interferon and anti-CD44 antibody. Anticancer Research. 20(6B): 4301-6, 2000.
  • Ma, XC.Gottschall, PE.Chen, LT.Wiranowska, M.Phelps, CP. Role and mechanisms of interleukin-1 in the modulation of neurotoxicity. Neuroimmunomodulation. 10(4): 199-207, 2002.
  • Wiranowska, M.Ladd, S.Smith, SR.Gottschall, PE. CD44 adhesion molecule and neuro-glial proteoglycan NG2 as invasive markers of glioma. Brain Cell Biology. 35(2-3): 159-72, 2006.
  • Wiranowska, M. and Plaas, A. Cytokines and Extracellular Matrix Remodeling in the Central Nervous System In: Neuroimmune Biology. 6, Cytokines and the Brain, Elsevier B.V. Science.(): , 2008.
  • Wiranowska, M, Ladd, S., Moscinski, L.C., Hill, B., Haller, E., Mikecz, K., Plass, A. Modulation of hyaluronan production by CD44 positive glioma cells. International Journal of Cancer . 127(): 532-542, 2010.
  • Roijani M.V., Wiranowska, M., and Roijani A.M. Matrix Metalloproteinases and Their Inhibitors-Friend or Foe in Tumor Microenvironment Tumor Microenvironment (Ed Dietmar W. Siemann) J. Wiley and Sons, Ltd.. (): 53-76, 2011.

    • Positions Held
  • Associate Professor (Department Pathology & Cell Biology, College of Medicine, University of South Florida 2006 - Present)
  • Associate Professor (Department of Anatomy, College of Medicine, University of South Florida 1995 - 2006)
  • Associate Professor (Department of Neurology, College of Medicine, University of South Florida 1994 - 1995)
  • Assistant Professor (Department of Neurology, College of Medicine, University of South Florida 1986 - 1994)
  • Associate in Research (Department of Internal Medicine, College of Medicine, University of South Florida 1985 - 1986)
  • Research Associate (Immunopharmacology Program, College of Medicine, University of South Florida 1982 - 1985)
  • Research Associate (Interferon Laboratories, Memorial Sloan-Kettering Cancer Center 1980 - 1981)
  • Research Assistant (Interferon Laboratories, Memorial Sloan-Kettering Cancer Center 1976 - 1980)
  • Research Assistant (Department of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer 1975 - 1976)
  • Research Assistant (Department of Histology and Biostructure, Medical Academy of Warsaw 1974 - 1975)


    • Memberships
  • USF Health Sciences Center Neuroscience Program (Founding Faculty Member/Group Leader for Brain Tumors Study Group, 1997 - Present)
  • American Association for Cancer Research (Member, 1993 - Present)
  • Moffitt Cancer Center Program (Member, 1993 - Present)
  • Neuro-Tumor Club, American Association for Cancer Research (Member, 1997 - 2000)
  • Eastern Cooperative Oncology Group (ECOG) (Member, 1994 - 2000)
  • Society for Neuroscience (Member, 1993 - 2000)
  • International Society for Interferon Research (Member, 1980 - 2000)
  • Tampa Bay Area Chapter Society for Neuroscience (Member, 1991 - 1999)
  • Tampa Bay Area Chapter Society for Neuroscience (Secretary/Treasurer, 1991 - 1993)


    • Awards/Honors
  • Special Invite: Author in the book project under working title Glioma, ISBN 978-953-307-379-8 (INTECH Open Access Publisher - 2011)
    		•
  • Invited Speaker for the 16th World Congress on Advances in Oncology and 14th International Symposium (Spandidos Publications Ltd. Athens Greece - 2011)
    		•
  • Participant (National Cancer Institute-Mouse Models of Human Cancer Consortium - 2005)
    		•
  • Special invite as Subject Specialist (Infography Fields of Knowledge in the area of "Malignant Glioma" - 2001)
    		•
  • Special invite: International collaborative study to develop international standards for interferon (World Health Organization (WHO) - 1995)
    		•
  • Basic Science Teaching Award (Department of Neurology, University of South Florida - 1993)
    		•


    Grants
  • EVALUATION OF GLIOMA TREATMENT: CONSULTANT AGREEMENT ($24,195.00, 11/01/2002-10/31/2009)
  • TM-601 ANIMAL EFFICACY STUDIES ($88,915.00, 07/01/2008-07/07/2009)
  • EVALUATION OF GLIOMA TREATMENT: CONSULTANT AGREEMENT ($23,354.00, 11/01/2002-10/31/2008)
  • TM0601 ANIMAL EFFICACY STUDIES ($67,401.00, 07/01/2005-06/30/2008)
  • TM0601 ANIMAL EFFICACY STUDIES ($55,000.00, 07/01/2005-06/30/2008)
  • EVALUATION OF GLIOMA TREATMENT: CONSULTANT AGREEMENT ($22,542.00, 11/01/2002-10/31/2007)
  • EVALUATION OF GLIOMA TREATMENT: CONSULTANT AGREEMENT ($21,759.00, 11/01/2002-10/31/2006)
  • TM0601 ANIMAL EFFICACY STUDIES ($3,000.00, 07/01/2005-06/30/2006)
  • TM601 ANIMAL EFFICACY STUDIES ($20,000.00, 07/01/2005-06/30/2006)
  • EVALUATION OF GLIOMA TREATMENT: CONSULTANT AGREEMENT ($21,003.00, 11/01/2002-10/31/2005)
  • TM601 ANIMAL EFFICACY STUDIES ($20,000.00, 07/01/2003-06/30/2005)
  • TM601 ANIMAL EFFICACY STUDIES ($18,394.00, 07/01/2003-06/30/2005)
  • TM601 ANIMAL EFFICACY STUDIES ($9,479.00, 07/01/2003-06/30/2005)
  • EVALUATION OF GLIOMA TREATMENT: CONSULTANT AGREEMENT ($15,003.00, 11/01/2002-10/31/2004)
  • EVALUATION OF GLIOMA TREATMENT: CONSULTANT AGREEMENT ($5,001.00, 11/01/2002-10/31/2004)
  • HYALADHERINS AND THEIR LIGANDS IN GLIOMA GROWTH AND INVASION ($50,000.00, 01/01/2002-12/31/2003)
  • EVALUATION OF GLIOMA TREATMENT: CONSULTANT AGREEMENT ($20,004.00, 07/01/2002-09/29/2003)
  • RESEARCH AGREEMENT: TM-601 PILOT ANIMAL EFFICACY STUDIES ($17,440.00, 07/01/2002-06/30/2003)
  • Interferon, the Blood-Brain Barrier and Glioma 1RO1-NS28989 ($508,370.00, 07/01/1990-12/31/1994)
  • Minority Investigator Supplement for Interferon, the Blood-Brain Barrier and Glioma 3RO1-NS28989 ($182,500.00, 01/01/1991-06/30/1993)


    • Lectures
  • "Clathrinmediated entry and cellular localization of chlorotoxin in glioma cells" TransMolecular Inc. Cambridge. MA, United States - 2009.
  • "Clathrinmediated entry and cellular localization of chlorotoxin in glioma cells and vascular endothelial cells" TransMolecular Inc.. MA, United States - 2009.
  • "Uptake of chlorotoxin by glioma cells in the live cultures" TransMolecular, Inc. Cambridge. MA, United States - 2007.
  • "Novel binding pattern of chlorotoxin (TM-601) in glioma cells" TransMolecular, Inc. Cambridge. MA, United States - 2006.
  • "Hyaladherins and their ligands in glioma growth and invasion" First Meeting of the Interdisciplinary Extracellular Group (ECM Group), College of Medicine, University of South Florida. FL, United States - 2003.
  • "Invasion, CD44 adhesion molecule, matrix proteins, and glioma survival" TransMolecular, Inc., Neuroscience Biotechnology Company. AL, United States - 2002.
  • "Graduate/Departmental Seminar: "All roads lead to Rome": Multiple pathways of interference with glioma progression: consideration of the adhesion molecule CD44 pathway" Department of Anatomy, University of South Florida, College of Medicine. FL, United States - 2001.
  • "Graduate/Departmental Seminar: Glioma invasion and angiogenesis: Current research and new approaches to brain tumor therapy" Department of Anatomy, University of South Florida College of Medicine. FL, United States - 2000.
  • "Glioma invasion, therapeutics delivery and CD44 adhesion molecule" Neuro-Oncology Program, H. Lee Moffitt Cancer Center and Research Institute. FL, United States - 1998.

    • Profile last modified on 02/17/2011