Molecular Pharmacology and Physiology
USF Health � College of Medicine
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Edwin Weeber , Ph.D.

Primary Department: COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Professor
COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY
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Contacts
Email: eweeber@health.usf.edu
Phone: (813) 396-9995
Office: ALZ, 310
Mailing address 4001 E Fletcher Ave ,Byrd 310
Tampa, FL 33613
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Education
  • Ph.D., Neuroscience, University of New Mexico ,USA - 2007.
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  • PhD, Neuroscience, University Of New Mexico College Of Medicine* , United States - 1998.
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  • B.S., Biology, University of New Mexico ,USA - 1993.
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    Interdisciplinary & Emerging Signature Programs
    Neuroscience, Biomedical Engineering & Nanomedicine.
     
    Research Summary

    The laboratory research programs center on reelin, Angelman Syndrome, ApoE and Alzheimer's Disease and neuroprosthetics. For details please visit the laboratoory website www.weeberlab.com

     
    Links

    Lab Link:  www.weeberlab.com


    Selected Publications
  • Selcher, JC.Weeber, EJ.Christian, J.Nekrasova, T.Landreth, GE.Sweatt, JD. A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. Learning & memory (Cold Spring Harbor, N.Y.). 10(1): 26-39, .
  • Frewin, CL.Jaroszeski, M.Weeber, E.Muffly, KE.Kumar, A.Peters, M.Oliveros, A.Saddow, SE. Atomic force microscopy analysis of central nervous system cell morphology on silicon carbide and diamond substrates. Journal of molecular recognition : JMR. 22(5): 380-8, .
  • Allan, AM.Weeber, EJ.Savage, DD.Caldwell, KK. Effects of prenatal ethanol exposure on phospholipase C-beta 1 and phospholipase A2 in hippocampus and medial frontal cortex of adult rat offspring. Alcoholism, clinical and experimental research. 21(8): 1534-41, 1997.
  • Weeber, EJ.Atkins, CM.Selcher, JC.Varga, AW.Mirnikjoo, B.Paylor, R.Leitges, M.Sweatt, JD. A role for the beta isoform of protein kinase C in fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(16): 5906-14, 2000.
  • Mirnikjoo, B.Brown, SE.Kim, HF.Marangell, LB.Sweatt, JD.Weeber, EJ. Protein kinase inhibition by omega-3 fatty acids. The Journal of biological chemistry. 276(14): 10888-96, 2001.
  • Seung Kim, HF.Weeber, EJ.Sweatt, JD.Stoll, AL.Marangell, LB. Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro. Molecular psychiatry. 6(2): 246-8, 2001.
  • Dineley, KT.Weeber, EJ.Atkins, C.Adams, JP.Anderson, AE.Sweatt, JD. Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination. Journal of neurochemistry. 77(4): 961-71, 2001.
  • Weeber, EJ.Savage, DD.Sutherland, RJ.Caldwell, KK. Fear conditioning-induced alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex. Neurobiology of learning and memory. 76(2): 151-82, 2001.
  • Levenson, JM.Weeber, EJ.Sweatt, JD.Eskin, A. Glutamate uptake in synaptic plasticity: from mollusc to mammal. Current molecular medicine. 2(7): 593-603, 2002.
  • Weeber, EJ.Levenson, JM.Sweatt, JD. Molecular genetics of human cognition. Molecular interventions. 2(6): 376-91, 339, 2002.
  • Watase, K.Weeber, EJ.Xu, B.Antalffy, B.Yuva-Paylor, L.Hashimoto, K.Kano, M.Atkinson, R.Sun, Y.Armstrong, DL.Sweatt, JD.Orr, HT.Paylor, R.Zoghbi, HY. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration. Neuron. 34(6): 905-19, 2002.
  • Selcher, JC.Weeber, EJ.Varga, AW.Sweatt, JD.Swank, M. Protein kinase signal transduction cascades in mammalian associative conditioning. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 8(2): 122-31, 2002.
  • Gu, Y.McIlwain, KL.Weeber, EJ.Yamagata, T.Xu, B.Antalffy, BA.Reyes, C.Yuva-Paylor, L.Armstrong, D.Zoghbi, H.Sweatt, JD.Paylor, R.Nelson, DL. Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(7): 2753-63, 2002.
  • Weeber, EJ.Levy, M.Sampson, MJ.Anflous, K.Armstrong, DL.Brown, SE.Sweatt, JD.Craigen, WJ. The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. The Journal of biological chemistry. 277(21): 18891-7, 2002.
  • Weeber, EJ.Sweatt, JD. Molecular neurobiology of human cognition. Neuron. 33(6): 845-8, 2002.
  • Levenson, J.Weeber, E.Selcher, JC.Kategaya, LS.Sweatt, JD.Eskin, A. Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake. Nature neuroscience. 5(2): 155-61, 2002.
  • Weeber, EJ.Beffert, U.Jones, C.Christian, JM.Forster, E.Sweatt, JD.Herz, J. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. The Journal of biological chemistry. 277(42): 39944-52, 2002.
  • Yoo, SY.Pennesi, ME.Weeber, EJ.Xu, B.Atkinson, R.Chen, S.Armstrong, DL.Wu, SM.Sweatt, JD.Zoghbi, HY. SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Neuron. 37(3): 383-401, 2003.
  • Hendricks, TJ.Fyodorov, DV.Wegman, LJ.Lelutiu, NB.Pehek, EA.Yamamoto, B.Silver, J.Weeber, EJ.Sweatt, JD.Deneris, ES. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron. 37(2): 233-47, 2003.
  • Sweatt, JD.Weeber, EJ.Lombroso, PJ. Genetics of childhood disorders: LI. Learning and memory, Part 4: Human cognitive disorders and the ras/ERK/CREB pathway. Journal of the American Academy of Child and Adolescent Psychiatry. 42(6): 741-4, 2003.
  • Chan, CS.Weeber, EJ.Kurup, S.Sweatt, JD.Davis, RL. Integrin requirement for hippocampal synaptic plasticity and spatial memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(18): 7107-16, 2003.
  • Sweatt, JD.Weeber, EJ. Genetics of childhood disorders: LII. Learning and memory, part 5: human cognitive disorders and the ras/ERK/CREB pathway. Journal of the American Academy of Child and Adolescent Psychiatry. 42(7): 873-6, 2003.
  • Weeber, EJ.Jiang, YH.Elgersma, Y.Varga, AW.Carrasquillo, Y.Brown, SE.Christian, JM.Mirnikjoo, B.Silva, A.Beaudet, AL.Sweatt, JD. Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(7): 2634-44, 2003.
  • Beffert, U.Weeber, EJ.Morfini, G.Ko, J.Brady, ST.Tsai, LH.Sweatt, JD.Herz, J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(8): 1897-906, 2004.
  • Opal, P.Garcia, JJ.McCall, AE.Xu, B.Weeber, EJ.Sweatt, JD.Orr, HT.Zoghbi, HY. Generation and characterization of LANP/pp32 null mice. Molecular and cellular biology. 24(8): 3140-9, 2004.
  • Marschang, P.Brich, J.Weeber, EJ.Sweatt, JD.Shelton, JM.Richardson, JA.Hammer, RE.Herz, J. Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Molecular and cellular biology. 24(9): 3782-93, 2004.
  • Weeber, EJ.Caldwell, KK. Delay fear conditioning modifies phospholipase C-beta 1a signaling in the hippocampus and frontal cortex. Pharmacology, biochemistry, and behavior. 78(1): 155-64, 2004.
  • May, P.Rohlmann, A.Bock, HH.Zurhove, K.Marth, JD.Schomburg, ED.Noebels, JL.Beffert, U.Sweatt, JD.Weeber, EJ.Herz, J. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Molecular and cellular biology. 24(20): 8872-83, 2004.
  • Strasser, V.Fasching, D.Hauser, C.Mayer, H.Bock, HH.Hiesberger, T.Herz, J.Weeber, EJ.Sweatt, JD.Pramatarova, A.Howell, B.Schneider, WJ.Nimpf, J. Receptor clustering is involved in Reelin signaling. Molecular and cellular biology. 24(3): 1378-86, 2004.
  • Beffert, U.Weeber, EJ.Durudas, A.Qiu, S.Masiulis, I.Sweatt, JD.Li, WP.Adelmann, G.Frotscher, M.Hammer, RE.Herz, J. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 47(4): 567-79, 2005.
  • Sinagra, M.Verrier, D.Frankova, D.Korwek, KM.Blahos, J.Weeber, EJ.Manzoni, OJ.Chavis, P. Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(26): 6127-36, 2005.
  • Chan, CS.Weeber, EJ.Zong, L.Fuchs, E.Sweatt, JD.Davis, RL. Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(1): 223-32, 2006.
  • Qiu, S.Zhao, LF.Korwek, KM.Weeber, EJ. Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(50): 12943-55, 2006.
  • Peters, MM.Hill, KE.Burk, RF.Weeber, EJ. Altered hippocampus synaptic function in selenoprotein P deficient mice. Molecular neurodegeneration. 1(): 12, 2006.
  • Nishijima, I.Yamagata, T.Spencer, CM.Weeber, EJ.Alekseyenko, O.Sweatt, JD.Momoi, MY.Ito, M.Armstrong, DL.Nelson, DL.Paylor, R.Bradley, A. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Human molecular genetics. 15(21): 3241-50, 2006.
  • Rebeck, GW.LaDu, MJ.Estus, S.Bu, G.Weeber, EJ. The generation and function of soluble apoE receptors in the CNS. Molecular neurodegeneration. 1(): 15, 2006.
  • Qiu, S.Korwek, KM.Pratt-Davis, AR.Peters, M.Bergman, MY.Weeber, EJ. Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice. Neurobiology of learning and memory. 85(3): 228-42, 2006.
  • Qiu, S.Korwek, KM.Weeber, EJ. A fresh look at an ancient receptor family: emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation. Neurobiology of learning and memory. 85(1): 16-29, 2006.
  • Beffert, U.Durudas, A.Weeber, EJ.Stolt, PC.Giehl, KM.Sweatt, JD.Hammer, RE.Herz, J. Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(7): 2041-52, 2006.
  • Bolognani, F.Qiu, S.Tanner, DC.Paik, J.Perrone-Bizzozero, NI.Weeber, EJ. Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD. Neurobiology of learning and memory. 87(4): 635-43, 2007.
  • Qiu, S.Weeber, EJ. Reelin signaling facilitates maturation of CA1 glutamatergic synapses. Journal of neurophysiology. 97(3): 2312-21, 2007.
  • van Woerden, GM.Harris, KD.Hojjati, MR.Gustin, RM.Qiu, S.de Avila Freire, R.Jiang, YH.Elgersma, Y.Weeber, EJ. Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. Nature neuroscience. 10(3): 280-2, 2007.
  • Qiu, S.Li, L.Weeber, EJ.May, JM. Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. Journal of neuroscience research. 85(5): 1046-56, 2007.
  • Gelinas, JN.Banko, JL.Hou, L.Sonenberg, N.Weeber, EJ.Klann, E.Nguyen, PV. ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation. The Journal of biological chemistry. 282(37): 27527-35, 2007.
  • Burk, RF.Hill, KE.Olson, GE.Weeber, EJ.Motley, AK.Winfrey, VP.Austin, LM. Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(23): 6207-11, 2007.
  • Levenson, JM.Qiu, S.Weeber, EJ. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Biochimica et biophysica acta. 1779(8): 422-31, 2008.
  • Fan, D.Yancey, PG.Qiu, S.Ding, L.Weeber, EJ.Linton, MF.Fazio, S. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry. 47(6): 1631-9, 2008.
  • Tanner, DC.Qiu, S.Bolognani, F.Partridge, LD.Weeber, EJ.Perrone-Bizzozero, NI. Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. Hippocampus. 18(8): 814-23, 2008.
  • Gelinas, JN.Banko, JL.Peters, MM.Klann, E.Weeber, EJ.Nguyen, PV. Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). 15(6): 403-11, 2008.
  • Yamagata, T.Urano, H.Weeber, EJ.Nelson, DL.Nishijima, I. Impaired hippocampal synaptic function in secretin deficient mice. Neuroscience. 154(4): 1417-22, 2008.
  • Rogers, JT.Weeber, EJ. Reelin and apoE actions on signal transduction, synaptic function and memory formation. Neuron glia biology. 4(3): 259-70, 2008.
  • Jinwal, UK.Miyata, Y.Koren, J.Jones, JR.Trotter, JH.Chang, L.O'Leary, J.Morgan, D.Lee, DC.Shults, CL.Rousaki, A.Weeber, EJ.Zuiderweg, ER.Gestwicki, JE.Dickey, CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(39): 12079-88, 2009.
  • Dumanis, SB.Tesoriero, JA.Babus, LW.Nguyen, MT.Trotter, JH.Ladu, MJ.Weeber, EJ.Turner, RS.Xu, B.Rebeck, GW.Hoe, HS. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48): 15317-22, 2009.
  • Korwek, KM.Trotter, JH.Ladu, MJ.Sullivan, PM.Weeber, EJ. ApoE isoform-dependent changes in hippocampal synaptic function. Molecular neurodegeneration. 4(): 21, 2009.
  • O'Leary, JC.Li, Q.Marinec, P.Blair, LJ.Congdon, EE.Johnson, AG.Jinwal, UK.Koren, J.Jones, JR.Kraft, C.Peters, M.Abisambra, JF.Duff, KE.Weeber, EJ.Gestwicki, JE.Dickey, CA. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular neurodegeneration. 5(): 45, 2010.
  • Qiu, S.Champagne, DL.Peters, M.Catania, EH.Weeber, EJ.Levitt, P.Pimenta, AF. Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit. Biological psychiatry. 68(2): 197-204, 2010.
  • Abisambra, JF.Blair, LJ.Hill, SE.Jones, JR.Kraft, C.Rogers, J.Koren, J.Jinwal, UK.Lawson, L.Johnson, AG.Wilcock, D.O'Leary, JC.Jansen-West, K.Muschol, M.Golde, TE.Weeber, EJ.Banko, J.Dickey, CA. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(46): 15374-82, 2010.
  • Liu, Q.Trotter, J.Zhang, J.Peters, MM.Cheng, H.Bao, J.Han, X.Weeber, EJ.Bu, G. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(50): 17068-78, 2010.
  • Gustin, RM.Bichell, TJ.Bubser, M.Daily, J.Filonova, I.Mrelashvili, D.Deutch, AY.Colbran, RJ.Weeber, EJ.Haas, KF. Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome. Neurobiology of disease. 39(3): 283-91, 2010.
  • Reddy, SS.Connor, TE.Weeber, EJ.Rebeck, W. Similarities and differences in structure, expression, and functions of VLDLR and ApoER2. Molecular neurodegeneration. 6(): 30, 2011.
  • Dumanis, SB.Cha, HJ.Song, JM.Trotter, JH.Spitzer, M.Lee, JY.Weeber, EJ.Turner, RS.Pak, DT.Rebeck, GW.Hoe, HS. ApoE receptor 2 regulates synapse and dendritic spine formation. PloS one. 6(2): e17203, 2011.
  • Jukkola, PI.Rogers, JT.Kaspar, BK.Weeber, EJ.Nishijima, I. Secretin deficiency causes impairment in survival of neural progenitor cells in mice. Human molecular genetics. 20(5): 1000-7, 2011.

    • Positions Held
  • Associate Professor (Molecular Pharmacology and Physiology, University of South Florida 2007 - Present)
  • Director (Murine Neurobehavioral Testing Facility, University of South Florida 2007 - Present)
  • Assistant Professor (Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center 2004 - 2007)
  • Assistant Professor (Department of Neuroscience, Baylor College of Medicine 2003 - 2004)
  • Reasearch Instructor (Department of Neuroscience, Baylor College of Medicine 2002 - 2003)


    • Memberships
  • American Society for Neurochemistry (ASN) (Member, 2004 - Present)
  • American Academy for the Advancement of Science (AAAS) (Member, 2004 - Present)
  • Molecular and Cellular Cognition Society (Member, 2002 - Present)
  • Society for Neuroscience (SFN) (Member, 1999 - Present)
  • Society for the Advancement of Chicanos and Native Americans in Science (Member, 1995 - Present)


    • Awards/Honors
  • Federation European Neuroscience Societies (FENS) Scientific Highlight of the Year Award ( - 2008)
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  • Med Scholars Mentoring Award (VUMC) ( - 2006)
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  • National Alliance for Research on Schizophrenia and Depression (NARSAD) Award ( - 2004)
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  • Cynthia and George Mitchell Award in Dementia Research ( - 2003)
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  • American Federation for Aging Research (AFAR) Award ( - 2003)
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    Grants
  • APOE EFFECTS ON NEURON SIGNALING AND FUNCTION VIA APOER2 ($278,643.00, 09/01/2010-08/31/2015)
  • APOE EFFECTS ON NEURON SIGNALING AND FUNCTION VIA APOER2 ($268,498.00, 09/01/2010-08/31/2015)
  • APOE EFFECTS ON NEURON SIGNALING AND FUNCTION VIA APOER2 ($290,548.00, 09/01/2010-08/31/2015)
  • MANIPULATING TEMPORAL AND SPACIAL CAMKII ACTIVITY IN ANGELMAN SYNDROME ($180,075.00, 08/20/2010-07/31/2013)
  • EXPLORING FDA APPROVED THERAPEUTIC STRATEGIES FOR THE TREATMENT OF ANGELMAN SYNDROME ($4,000.00, 07/01/2011-06/30/2013)
  • EXPLORING FDA APPROVED THERAPEUTIC STRATEGIES FOR THE TREATMENT OF ANGELMAN SYNDROME ($52,000.00, 07/01/2011-06/30/2013)
  • EXPLORING FDA APPROVED THERAPEUTIC STRATEGIES FOR THE TREATMENT OF ANGELMAN SYNDROME ($52,000.00, 07/01/2011-06/30/2013)
  • APOE RECEPTOR BIOLOGY AND NEURODEGENERATION ($258,985.00, 08/15/2009-06/30/2013)
  • APOE RECEPTOR BIOLOGY AND NEURODEGENERATION ($256,428.00, 08/15/2009-06/30/2013)
  • LONG TERM INTERFACING AND SIGNALING OF NEURONAL TISSUE USING SILICON CARBIDE MICRO-ELECTROMECHANICAL SYSTEMS ($51,326.00, 09/30/2010-09/29/2012)
  • LONG TERM INTERFACING AND SIGNALING OF NEURONAL TISSUE USING SILICON CARBIDE MICRO-ELECTROMECHANICAL SYSTEMS ($50,306.00, 09/30/2010-09/29/2012)
  • MANIPULATING TEMPORAL AND SPACIAL CAMKII ACTIVITY IN ANGELMAN SYNDROME ($220,500.00, 08/20/2010-07/31/2012)
  • APOE RECEPTOR BIOLOGY AND NEURODEGENERATION ($240,344.00, 08/15/2009-06/30/2012)
  • THERAPEUTIC INTERVENTIONS FOR ANGELMAN SYNDROME ($52,622.00, 02/04/2010-02/28/2012)
  • THERAPEUTIC INTERVENTIONS FOR ANGELMAN SYNDROME ($28,263.00, 02/04/2010-02/28/2012)
  • MECHANISMS OF CYTOREG THERAPY ($35,209.00, 10/01/2011-02/06/2012)
  • NOVEL THERAPEUTIC STRATEGIES FOR TREATMENT OF ANGELMAN SYNDROME ($220,500.00, 09/26/2010-08/31/2011)
  • APOE RECEPTOR BIOLOGY AND NEURODEGENERATION ($240,345.00, 08/15/2009-06/30/2010)
  • MECHANISMS OF REELIN SIGNALING IN THE ADULT HIPPOCAMPUS ($275,619.00, 07/15/2008-05/31/2010)
  • MECHANISMS OF REELIN SIGNALING IN THE ADULT HIPPOCAMPUS ($247,048.00, 07/15/2008-05/31/2010)
  • THERAPEUTIC EFFECTIVENESS OF LEVODOPA IN THE TREATMENT OF SEIZURES AND MOTOR DEFECTS USING THE ANGELMAN SYNDROME MOUSE MODEL ($50,000.00, 03/01/2008-02/28/2009)
  • IDENTIFYING POTENTIAL THERAPEUTIC STRATEGIES FO THE TREATMENT OF ANGELMAN SYNDROME ($62,200.00, 02/01/2008-01/31/2009)
  • Mechanisms of Reelin Signaling in the Adult Hippocampus ($1,369,115.00, 06/01/2004-05/31/2008)


    • Lectures
  • "The use of a mouse model for human Angelman Syndrome to explore potential therapeutics" " ACNP Conference minisymposia. FL, United States - 2010.
  • "Future of therspeutics for ANgelman Syndrome" " A night of Angels, Fundraising Gala. NY, United States - 2010.
  • "A new role for ancient lipoprotein receptors in learning, memory and therapeutics" " Mayo Clinic Jacksonville. FL, United States - 2010.
  • "Genetic and pharmacological strategies for paternal Ube3a expression" " Canadian Angelman Syndrome Society (CASS) . Canada - 2010.
  • "ApoER2 activation in mammalian learning and memory" " Washington University. MO, United States - 2010.
  • "The role of apoE receptors in cognitive ability and as a potential therapeutic target" " Byrd Alzheimers Research Institute Translational Seminar. FL, United States - 2010.
  • "Insights from the UBE3A maternal deficient mouse model" " Baylor College of Medicine. TX, United States - 2010.
  • "The role of Reelin in mammalian cognitive ability" " Winter Brain Conference. CO, United States - 2010.
  • "Identifying memory molecules: a story of receptors, the synapse and cognitive ability" " Princeton University. NJ, United States - 2009.
  • "Recent advancements and future directions in Angelman Syndrome research" " Angelman Syndrome Foundation Annual Conference. FL, United States - 2009.
  • "Angelman Syndrome Research: a year in review" " Angelman Syndrome Gala. IL, United States - 2009.
  • "Effects of Reelin on the cognitive and physiologic deficits in the AS mouse model" " Angelman Syndrome Foundation Annual Conference. FL, United States - 2009.
  • "Implications of the mouse model for Angelman Syndrome and the future of AS research" " Sydney Childrens Hospital. Australia - 2009.
  • "Understanding Angelman syndrome and predicting future therapeutics" " Sydney Childrens Hospital. Australia - 2009.
  • "Identification, Clinical diagnosis and genetic testing for Angelman Syndrome" Sydney Childrens Hospital. Australia - 2009.
  • "Genetics, biochemistry and pathology of Angelman Syndrome" Mater Hospital. Australia - 2009.
  • "Implications of the mouse model for Angelman Syndrome and the future of AS research" Mater Hospital. Australia - 2009.
  • "Learning from mouse models of human cognitive disorders" " University of California. CA, United States - 2009.
  • "Ancient receptors, newly identified ligands and cognitive ability" " University of Hawaii. HI, United States - 2009.
  • "The use of Silicon Carbide Brain Interface Devices in the activation of neurons" " Joint presentation, Engineering-Neuroscience. FL, United States - 2009.
  • "The effects of Levadopa on a mouse model for Human Angleman Syndrome" " Keystone Conference  Epigenetics of human disorders. CO, United States - 2009.
  • "The role of ApoE isoforms in hippocampus synaptic function" " United Kingdom Minisymposia . FL, United States - 2009.
  • "Molecular alterations in Angelman Syndrome " " University of Texas, Southwest (UTSW). TX, United States - 2008.
  • "Therapeutic approaches for the treatment of seizure and cognitive dysfunction in Angelman Syndrome" " Canadian Angelman Syndrome Society (CASS). Canada - 2008.
  • "ApoE isoform-dependent changes in hippocampal synaptic plasticity" " Mini Symposium on Apolipoprotein E. University of Kentucky. KY, United States - 2008.
  • "" Angelman Syndrome Gala" Development and usefulness of a mouse model for Angelman Syndrome. IL, United States - 2008.
  • "Molecular Changes in Angelman Syndrome; The First Curable Human Cognitive Disorder?" " Medical College of Wisconsin. WI, United States - 2008.
  • "Rescuing the phenotypes of Angelman Syndrome" " Winter Brain Conference - Neurobiology of Learning & Memory. UT, United States - 2008.
  • "Reelin and ApoE effects on synaptic plasticity, maturation and receptor complement" " Galenea Corp. MA, United States - 2008.

    • Profile last modified on 02/20/2013