Molecular Pharmacology and Physiology
USF Health � College of Medicine
Login here to update your profile  
My Profile

Javier Cuevas , Ph.D.

Primary Department: COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Assoc Professor
COP DEPT OF PHARMACEUTICAL SCIENCE

Professor
COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY
profile Image
Contacts
Email: jcuevas@health.usf.edu
Phone: (813) 974-4678
Office: MDC, 4038
Mailing address 12901 Bruce B. Downs Blvd. ,MDC 8
Tampa, FL 33612
View My C.V.
 
Education
  • PHD, Molecular and Cellular Pharmacology, University Of Miami , Miami, United States - 1995.
    		•
  • BA, Biology/Psychology, Dartmouth ,USA - 1988.
    		•
     
    Interdisciplinary & Emerging Signature Programs
    Neuroscience, Cardiovascular.
     
    Links
    Personal Page:   http://scholar.google.com/citations?hl=en&user=cDcB-C4AAAAJ&view_op=list_works&pagesize=100
    Lab Link:  http://health.usf.edu/medicine/mpp/index.htm


    Selected Publications
  • Cameron, JS.Gaide, MS.Goad, PL.Altman, CB.Cuevas, J.Myerburg, RJ.Bassett, AL. Enhanced adverse electrophysiologic effects of histamine after myocardial infarction in guinea pigs. The Journal of pharmacology and experimental therapeutics. 232(2): 480-4, 1985.
  • Kimura, S.Bassett, AL.Furukawa, T.Cuevas, J.Myerburg, RJ. Electrophysiological properties and responses to simulated ischemia in cat ventricular myocytes of endocardial and epicardial origin. Circulation research. 66(2): 469-77, 1990.
  • Cuevas, J.Bassett, AL.Cameron, JS.Furukawa, T.Myerburg, RJ.Kimura, S. Effect of H+ on ATP-regulated K+ channels in feline ventricular myocytes. The American journal of physiology. 261(3 Pt 2): H755-61, 1991.
  • Cuevas, J.Adams, DJ. Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells. British journal of pharmacology. 111(3): 663-72, 1994.
  • Cuevas, J.Adams, DJ. Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones. The Journal of physiology. 493 ( Pt 2)(): 503-15, 1996.
  • Cuevas, J.Adams, DJ. M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons. Journal of neurophysiology. 78(4): 1903-12, 1997.
  • Cuevas, J.Harper, AA.Trequattrini, C.Adams, DJ. Passive and active membrane properties of isolated rat intracardiac neurons: regulation by H- and M-currents. Journal of neurophysiology. 78(4): 1890-902, 1997.
  • Poth, K.Nutter, TJ.Cuevas, J.Parker, MJ.Adams, DJ.Luetje, CW. Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17(2): 586-96, 1997.
  • Loughnan, M.Bond, T.Atkins, A.Cuevas, J.Adams, DJ.Broxton, NM.Livett, BG.Down, JG.Jones, A.Alewood, PF.Lewis, RJ. alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors. The Journal of biological chemistry. (25): , 1998.
  • Cuevas, J.Berg, DK. Mammalian nicotinic receptors with alpha7 subunits that slowly desensitize and rapidly recover from alpha-bungarotoxin blockade. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18(24): 10335-44, 1998.
  • Liu, DM.Cuevas, J.Adams, DJ. VIP and PACAP potentiation of nicotinic ACh-evoked currents in rat parasympathetic neurons is mediated by G-protein activation. The European journal of neuroscience. (7): , 2000.
  • Cuevas, J.Roth, AL.Berg, DK. Two distinct classes of functional 7-containing nicotinic receptor on rat superior cervical ganglion neurons. The Journal of physiology. 525 Pt 3(): 735-46, 2000.
  • Cuevas, J.Adams, DJ. Substance P preferentially inhibits large conductance nicotinic ACh receptor channels in rat intracardiac ganglion neurons. Journal of neurophysiology. 84(4): 1961-70, 2000.
  • Zhang, H.Cuevas, J. Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. Journal of neurophysiology. (6): , 2002.
  • DeHaven, WI.Cuevas, J. Heterogeneity of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide receptors in rat intrinsic cardiac neurons. Neuroscience letters. (1): , 2002.
  • Severance, EG.Cuevas, J. Distribution and synaptic localization of nicotinic acetylcholine receptors containing a novel alpha7 subunit isoform in embryonic rat cortical neurons. Neuroscience letters. (1-2): , 2004.
  • Sawmiller, DR.Henning, RJ.Cuevas, J.Dehaven, WI.Vesely, DL. Coronary vascular effects of vasoactive intestinal peptide in the isolated perfused rat heart. Neuropeptides. (5): , 2004.
  • Herber, DL.Severance, EG.Cuevas, J.Morgan, D.Gordon, MN. Biochemical and histochemical evidence of nonspecific binding of alpha7nAChR antibodies to mouse brain tissue. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. (10): , 2004.
  • Severance, EG.Zhang, H.Cruz, Y.Pakhlevaniants, S.Hadley, SH.Amin, J.Wecker, L.Reed, C.Cuevas, J. The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. Molecular pharmacology. (3): , 2004.
  • DeHaven, WI.Cuevas, J. VPAC receptor modulation of neuroexcitability in intracardiac neurons: dependence on intracellular calcium mobilization and synergistic enhancement by PAC1 receptor activation. The Journal of biological chemistry. (39): , 2004.
  • Zhang, H.Cuevas, J. sigma Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons. The Journal of pharmacology and experimental therapeutics. (3): , 2005.
  • Ajmo, CT.Vernon, DO.Collier, L.Pennypacker, KR.Cuevas, J. Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats. Current neurovascular research. (2): , 2006.
  • Katnik, C.Guerrero, WR.Pennypacker, KR.Herrera, Y.Cuevas, J. Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. The Journal of pharmacology and experimental therapeutics. (3): , 2006.
  • Henning, RJ.Cuevas, J. Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. Journal of cardiovascular pharmacology. (1): , 2006.
  • Song, S.Song, S.Zhang, H.Cuevas, J.Sanchez-Ramos, J. Comparison of neuron-like cells derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem cells and development. (5): , 2007.
  • McCord, AM.Cuevas, J.Anderson, BE. Bartonella-induced endothelial cell proliferation is mediated by release of calcium from intracellular stores. DNA and cell biology. (9): , 2007.
  • Zhang, H.Katnik, C.Cuevas, J. Sigma receptor activation inhibits voltage-gated sodium channels in rat intracardiac ganglion neurons. International journal of physiology, pathophysiology and pharmacology. 2(1): 1-11, 2009.
  • Pollock, VV.Pastoor, T.Katnik, C.Cuevas, J.Wecker, L. Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate alpha4beta2 nicotinic receptor subunits at distinct stages of receptor formation and maturation. Neuroscience. 158(4): 1311-25, 2009.
  • Hall, AA.Herrera, Y.Ajmo, CT.Cuevas, J.Pennypacker, KR. Sigma receptors suppress multiple aspects of microglial activation. Glia. 57(7): 744-54, 2009.
  • Ajmo, CT.Collier, LA.Leonardo, CC.Hall, AA.Green, SM.Womble, TA.Cuevas, J.Willing, AE.Pennypacker, KR. Blockade of adrenoreceptors inhibits the splenic response to stroke. Experimental neurology. 218(1): 47-55, 2009.
  • Cortes-Salva, M.Nguyen, BL.Cuevas, J.Pennypacker, KR.Antilla, JC. Copper-catalyzed guanidinylation of aryl iodides: the formation of N,N'-disubstituted guanidines. Organic letters. 12(6): 1316-9, 2010.
  • Mari, Y.Katnik, C.Cuevas, J. ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. Cell calcium. 48(1): 70-82, 2010.
  • Yanamandra, N.Buzzeo, RW.Gabriel, M.Hazlehurst, LA.Mari, Y.Beaupre, DM.Cuevas, J. Tipifarnib-Induced Apoptosis in Acute Myeloid Leukemia and Multiple Myeloma Cells Depends on Ca2+ Influx through Plasma Membrane Ca2+ Channels. The Journal of pharmacology and experimental therapeutics. 337(3): 636-43, 2011.

    • Positions Held
  • Professor (Department of Molecular Pharmacology and Physiology, College of Medicine , University of South Florida 2012 - Present)
  • Professor (Pharmaceutical Sciences, College of Pharmacy, University of South Florida 2012 - Present)
  • Associate Professor (Department of Molecular Pharmacology and Physiology, College of Medicine , University of South Florida 2006 - Present)
  • Member (Department of Molecular Pharmacology and Physiology Executive Committee, College of Medicine, University of South Florida 2006 - Present)
  • Member (Neuroscience Signature Program Executive Committee, College of Medicine, University of South Florida 2006 - Present)
  • Member (Diversity and Equal Opportunity Office, University of South Florida Health Science Center Liaison 2005 - Present)
  • Associate Professor (Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida 2005 - 2006)
  • Assistant Professor (Department of Pharmacology and Therapeutics, College of Medicine , University of South Florida 1999 - 2005)


    • Memberships
  • American Heart Association (Member, 2006 - Present)
  • Society for Neuroscience (Member, 1999 - Present)
  • American Society for Pharmacology and Experimental Therapeutics (member, 1999 - Present)


    • Awards/Honors
  • Biotechnology Excellence Award (University of South Florida College of Medicine - 2006)
    		•
  • Outstanding Mentor (University of South Florida McNair Scholars Program - 2004)
    		•


    Patents & Licensing
  • Effective treatment with sigma receptor agonists post-stroke. (USF-05A046PR, U.S. patent pending. - 2005)
  • Screening for New Agents for Post-Stroke Treatment. (USF-05B105, U.S. patent pending. - 2005)
  • Novel exon (4a) in the rat alpha7 nicotinic receptor subunit gene and resulting isoform. (USF-185CXC1, U.S. patent pending - 2003)


    • Grants
  • MOLECULAR MECHANISMS OF SIGMA RECEPTOR-MEDIATED CYTOPROTECTION ($82,500.00, 07/01/2011-06/30/2013)
  • MOLECULAR MECHANISMS OF SIGMA RECEPTOR-MEDIATED CYTOPROTECTION ($82,500.00, 07/01/2011-06/30/2013)
  • NEUROPROTECTIVE PROPERTIES OF AFOBASOL MODELED IN VIVO ($56,015.00, 03/01/2011-12/01/2012)
  • ROLE OF CALCIUM IN MEDIATING C-HYD1 AND HYD1 INDUCED CELL DEATH IN MULTIPLE MYELOMA ($7,094.00, 12/01/2010-11/30/2012)
  • ROLE OF CALCIUM IN MEDIATING C-HYD1 AND HYD1 INDUCED CELL DEATH IN MULTIPLE MYELOMA ($6,888.00, 12/01/2010-11/30/2012)
  • NEUROPROTECTIVE PROPERTIES OF AFOBASOL MODELED IN VIVO ($369,968.00, 03/01/2011-07/31/2012)
  • NEUROPROTECTIVE PROPERTIES OF AFOBASOL MODELED IN VITRO ($93,767.00, 03/01/2011-01/31/2012)
  • REGULATION OF INTRACARDIAC NEURON EXCITABILITY BY STORE-OPERATED CALCIUM CHANNELS ($23,500.00, 09/01/2010-08/31/2011)
  • MECHANISMS REGULATING INTRACARDIAC NEURON EXCITABILITY ($88,000.00, 07/01/2007-06/30/2011)
  • EFFECTS OF AFOBASOL ON CALCIUM HANDLING IN NEURONS DURING ISCHEMIA ($44,825.00, 09/21/2009-09/30/2010)
  • EFFECTS OF AFOBASOL ON CALCIUM HANDLING IN NEURONS AND MICROGLIA ($85,298.00, 09/21/2009-09/30/2010)
  • MECHANISMS REGULATING INTRACARDIAC NEURON EXCITABILITY ($88,000.00, 07/01/2007-06/30/2010)
  • MECHANISMS REGULATING INTRACARDIAC NEURON EXCITABILITY ($88,000.00, 07/01/2007-06/30/2010)
  • Synthesis and screening of sigma receptor ligands for stroke therapy at delayed time points ($75,000.00, 02/01/2008-01/30/2009)
  • SIGMA RECEPTOR-MEDIATED NEUROPROTECTION DURING ISCHEMIA ($60,000.00, 07/01/2004-12/30/2006)
  • SIGMA RECEPTOR-MEDIATED NEUROPROTECTION DURING ISCHEMIA ($60,000.00, 07/01/2004-06/30/2006)
  • EFFECTS OF SIGMA RECEPTORS ON NEUROEXITABILITY OF RAT INTRACARDIAC NEURONS (PRE-DOCTORAL FELLOWSHIP FOR HONGLING ZHANG) ($38,000.00, 07/01/2003-06/30/2005)
  • VIP AND PACAP REGULATION OF NEUROEXITABILITY IN NEURONS OF THE MAMMALIAN INTRACARDIAC GANGLION (PREDOCTORAL FELLOWSHIP FOR WAYNE ISLEY DEHAVEN) ($38,000.00, 07/01/2003-06/30/2004)
  • NICOTINIC RECEPTORS IN MAMMALIAN INTRACARDIAC NEURONS ($160,224.00, 09/01/1999-08/31/2002)
  • NICOTINIC RECEPTORS IN MAMMALIAN INTRACARDIAC NEURONS ($155,557.00, 09/01/1999-08/31/2002)


    • Lectures
  • "Expanding the Therapeutic Window for Ischemic Stroke" University of Toledo. FL, United States - 2008.
  • "Novel Therapies for Ischemic Stroke" Howard University. FL, United States - 2008.
  • "Fostering active learning from laboratory to bedside, from student to clinician" University of Central Florida. FL, United States - 2008.
  • "Overview and Treatment of Congestive Heart Failure" Hospice of the Florida Suncoast. FL, United States - 2008.
  • "Vasoactive Peptides" Hospice of the Florida Suncoast. FL, United States - 2008.

    • Profile last modified on 05/14/2013