Molecular Pharmacology and Physiology
USF Health � College of Medicine
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Keith Pennypacker , Ph.D.

Primary Department: COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Assoc Professor
COLLEGE OF MEDICINE NEUROSURGERY

Professor
COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Professor
COLLEGE OF MEDICINE NEUROLOGY

Professor
COLLEGE OF MEDICINE PSYCHIATRY AND BEHAVIORAL NEUROSCIENCES

Professor
COP DEPT OF PHARMACEUTICAL SCIENCE
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Contacts
Email: kpennypa@health.usf.edu
Phone: (813) 974-9913
Office: MDC, 4029
Mailing address 12901 Bruce B. Downs Blvd. ,MDC 8
Tampa, FL 33612
View My C.V.
 
Education
  • PHD, Pharmacology, Pennsylvania State University , Hershey, United States - 1987.
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  • MS, Neurobiology, Virginia Commonwealth University ,USA - 1984.
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  • BA, Biology, Millersville University ,USA - 1982.
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    Interdisciplinary & Emerging Signature Programs
    Cardiovascular, Neuroscience.
     
    Research Summary

    The lab focuses on the role of the peripheral immune system in ischemic and traumatic brain injury. Novel therapeutic strategies for brain injuries are being investigated by examining signal transduction pathways that enhance the survival of neuronal cells and reduce inflammation.

     
    Links
    Personal Page:   http://scholar.google.com/citations?user=r3TEpZwAAAAJ&hl=en


    Selected Publications
  • Pennypacker, KR.Lennard, DE.Hudson, PM.Hong, JS.McMillian, MK. Basal expression of 35 kDa fos-related antigen in olfactory bulb. Brain research. Molecular brain research. 34(1): 161-5, 1995.
  • Pennypacker, KR.Hong, JS.McMillian, MK. Implications of prolonged expression of Fos-related antigens. Trends in pharmacological sciences. 16(9): 317-21, 1995.
  • Pérez-Otano, I.McMillian, MK.Chen, J.Bing, G.Hong, JS.Pennypacker, KR. Induction of NF-kB-like transcription factors in brain areas susceptible to kainate toxicity. Glia. 16(4): 306-15, 1996.
  • Bing, G.McMillian, M.Kim, H.Pennypacker, K.Feng, Z.Qi, Q.Kong, LY.Iadarola, M.Hong, JS. Long-term expression of the 35,000 mol. wt fos-related antigen in rat brain after kainic acid treatment. Neuroscience. 73(4): 1159-74, 1996.
  • Bronstein, DM.Pennypacker, KR.Lee, H.Hong, JS. Methamphetamine-induced changes in AP-1 binding and dynorphin in the striatum: correlated, not causally related events? Biological signals. 5(6): 317-33, 1996.
  • Pennypacker, KR.Hong, JS.Mullis, SB.Hudson, PM.McMillian, MK. Transcription factors in primary glial cultures: changes with neuronal interactions. Brain research. Molecular brain research. 37(1-2): 224-30, 1996.
  • Blazka, ME.Bruccoleri, A.Simeonova, PP.Germolec, DR.Pennypacker, KR.Luster, MI. Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity. Research communications in molecular pathology and pharmacology. 92(3): 259-73, 1996.
  • Blazka, M. Germolec, DR. Simeonova, P. Bruccoleri, A. Pennypacker, KR. Luster, MI. Acetomeinophen-induced hepatotxicity is associated with early changes in NF-kB and NF-IL6 DNA binding actvity. J Inflammation. 47(3): 138-50, 1996.
  • McMillian, MK.Pennypacker, KR.Thai, L.Wu, GC.Suh, HH.Simmons, KL.Hudson, PM.Sawin, SB.Hong, JS. Dexamethasone and forskolin synergistically increase [Met5]enkephalin accumulation in mixed brain cell cultures. Brain research. 730(1-2): 67-74, 1996.
  • Kim, HC.Pennypacker, KR.Bing, G.Bronstein, D.McMillian, MK.Hong, JS. The effects of dextromethorphan on kainic acid-induced seizures in the rat. Neurotoxicology. 17(2): 375-85, 1996.
  • Pennypacker, KR.Xiao, Y.Xu, RH.Harry, GJ. Lead-induced developmental changes in AP-1 DNA binding in rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 15(3): 321-8, 1997.
  • Pennypacker, K. Transcription factors in brain injury. Histology and histopathology. 12(4): 1125-33, 1997.
  • Pennypacker, K. AP-1 transcription factors: short- and long-term modulators of gene expression in the brain. International review of neurobiology. 42(): 169-97, 1998.
  • Pennypacker, KR.Fuldner, R.Xu, R.Hernandez, H.Dawbarn, D.Mehta, N.Perez-Tur, J.Baker, M.Hutton, M. Cloning and characterization of the presenilin-2 gene promoter. Brain research. Molecular brain research. 56(1-2): 57-65, 1998.
  • Pennypacker, KR.Hernandez, H.Benkovic, S.Morgan, DG.Willing, AE.Sanberg, PR. Induction of presenilins in the rat brain after middle cerebral arterial occlusion. Brain research bulletin. 48(5): 539-43, 1999.
  • Xiao, Y.Harry, GJ.Pennypacker, KR. Expression of AP-1 transcription factors in rat hippocampus and cerebellum after trimethyltin neurotoxicity. Neurotoxicology. 20(5): 761-6, 1999.
  • Bruccoleri, A.Pennypacker, KR.Harry, GJ. Effect of dexamethasone on elevated cytokine mRNA levels in chemical-induced hippocampal injury. Journal of neuroscience research. 57(6): 916-26, 1999.
  • Pennypacker, KR.Kassed, CA.Eidizadeh, S.O'Callaghan, JP. Brain injury: prolonged induction of transcription factors. Acta neurobiologiae experimentalis. 60(4): 515-30, 2000.
  • O'Callaghan, JP.Miller, DB.Pennypacker, KR. Chronic dopaminergic signaling in the basal ganglia: a damage perspective on kinases and fos-related antigens. Addiction biology. 5(3): 369-76, 2000.
  • Pennypacker, KR.Yang, X.Gordon, MN.Benkovic, S.Miller, D.O'Callaghan, JP. Long-term induction of Fos-related antigen-2 after methamphetamine-, methylenedioxymethamphetamine-, 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine- and trimethyltin-induced brain injury. Neuroscience. 101(4): 913-9, 2000.
  • Pennypacker, KR.Eidizadeh, S.Kassed, CA.O'Callaghan, JP.Sanberg, PR.Willing, AE. Expression of fos-related antigen-2 in rat hippocampus after middle cerebral arterial occlusion. Neuroscience letters. 289(1): 1-4, 2000.
  • Hakki, A.Pennypacker, K.Eidizadeh, S.Friedman, H.Pross, S. Nicotine inhibition of apoptosis in murine immune cells. Experimental biology and medicine (Maywood, N.J.). 226(10): 947-53, 2001.
  • Pennypacker, KR.Kassed, CA.Eidizadeh, S.Saporta, S.Sanberg, PR.Willing, AE. NF-kappaB p50 is increased in neurons surviving hippocampal injury. Experimental neurology. 172(2): 307-19, 2001.
  • Pennypacker, KR. Hong, JS. Fos-related antigen Encyclopedia Molecular Medicine. 5(): 1319-20, 2002.
  • Kassed, CA.Willing, AE.Garbuzova-Davis, S.Sanberg, PR.Pennypacker, KR. Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning. Experimental neurology. 176(2): 277-88, 2002.
  • Butler, TL.Kassed, CA.Sanberg, PR.Willing, AE.Pennypacker, KR. Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion. Brain research. 929(2): 252-60, 2002.
  • Butler, TL.Kassed, CA.Pennypacker, KR. Signal transduction and neurosurvival in experimental models of brain injury. Brain research bulletin. 59(5): 339-51, 2003.
  • Kassed, CA.Butler, TL.Navidomskis, MT.Gordon, MN.Morgan, D.Pennypacker, KR. Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-kappaB p50 in hippocampal neurons after injury. Brain research. Molecular brain research. 110(1): 152-7, 2003.
  • Kassed, CA.Butler, TL.Patton, GW.Demesquita, DD.Navidomskis, MT.Mémet, S.Israël, A.Pennypacker, KR. Injury-induced NF-kappaB activation in the hippocampus: implications for neuronal survival. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18(6): 723-4, 2004.
  • Dickey, CA.De Mesquita, DD.Morgan, D.Pennypacker, KR. Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells. Neuroscience letters. 366(1): 10-4, 2004.
  • Butler, TL.Pennypacker, KR. Temporal and regional expression of Fos-related proteins in response to ischemic injury. Brain research bulletin. 63(1): 65-73, 2004.
  • Vendrame, M.Cassady, J.Newcomb, J.Butler, T.Pennypacker, KR.Zigova, T.Sanberg, CD.Sanberg, PR.Willing, AE. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke; a journal of cerebral circulation. 35(10): 2390-5, 2004.
  • Duckworth, EA.Butler, TL.De Mesquita, D.Collier, SN.Collier, L.Pennypacker, KR. Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration. Brain research. 1042(1): 29-36, 2005.
  • Butler, TL.Pennypacker, KR. The transcriptional response to hypoxic insult controlled by FRA-2. Gene expression. 12(2): 61-7, 2005.
  • Pollock, G.Pennypacker, KR.Mémet, S.Israël, A.Saporta, S. Activation of NF-kappaB in the mouse spinal cord following sciatic nerve transection. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. 165(4): 470-7, 2005.
  • Vendrame, M.Gemma, C.de Mesquita, D.Collier, L.Bickford, PC.Sanberg, CD.Sanberg, PR.Pennypacker, KR.Willing, AE. Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem cells and development. 14(5): 595-604, 2005.
  • Vendrame, M.Gemma, C.Pennypacker, KR.Bickford, PC.Davis Sanberg, C.Sanberg, PR.Willing, AE. Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Experimental neurology. 199(1): 191-200, 2006.
  • Newcomb, JD.Ajmo, CT.Sanberg, CD.Sanberg, PR.Pennypacker, KR.Willing, AE. Timing of cord blood treatment after experimental stroke determines therapeutic efficacy. Cell transplantation. 15(3): 213-23, 2006.
  • Ajmo, CT.Vernon, DO.Collier, L.Pennypacker, KR.Cuevas, J. Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats. Current neurovascular research. 3(2): 89-98, 2006.
  • Vernon, DO.Garbuzova-Davis, S.Desjarlais, T.Singh Rasile, R.Sanberg, PR.Willing, AE.Pennypacker, KR. Reduced Nuclear Factor kappa B activation in dentate gyrus after active avoidance training. Brain research. 1104(1): 39-44, 2006.
  • Duckworth, EA.Butler, T.Collier, L.Collier, S.Pennypacker, KR. NF-kappaB protects neurons from ischemic injury after middle cerebral artery occlusion in mice. Brain research. 1088(1): 167-75, 2006.
  • Katnik, C.Guerrero, WR.Pennypacker, KR.Herrera, Y.Cuevas, J. Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. The Journal of pharmacology and experimental therapeutics. 319(3): 1355-65, 2006.
  • Willing, AE.Pennypacker, KR. Alternate approach to understanding the molecular mechanisms of stroke-induced injury. Histology and histopathology. 22(6): 697-701, 2007.
  • Ajmo, CT.Vernon, DO.Collier, L.Hall, AA.Garbuzova-Davis, S.Willing, A.Pennypacker, KR. The spleen contributes to stroke-induced neurodegeneration. Journal of neuroscience research. 86(10): 2227-34, 2008.
  • Leonardo, CC.Eakin, AK.Ajmo, JM.Collier, LA.Pennypacker, KR.Strongin, AY.Gottschall, PE. Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat. Journal of neuroinflammation. 5(): 34, 2008.
  • Herrera, Y.Katnik, C.Rodriguez, JD.Hall, AA.Willing, A.Pennypacker, KR.Cuevas, J. Sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons. The Journal of pharmacology and experimental therapeutics. 327(2): 491-502, 2008.
  • Ajmo, CT.Collier, LA.Leonardo, CC.Hall, AA.Green, SM.Womble, TA.Cuevas, J.Willing, AE.Pennypacker, KR. Blockade of adrenoreceptors inhibits the splenic response to stroke. Experimental neurology. 218(1): 47-55, 2009.
  • Leonardo, CC.Pennypacker, KR. Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injury. Journal of neuroinflammation. 6(): 13, 2009.
  • Hall, AA.Herrera, Y.Ajmo, CT.Cuevas, J.Pennypacker, KR. Sigma receptors suppress multiple aspects of microglial activation. Glia. 57(7): 744-54, 2009.
  • Hall, AA.Guyer, AG.Leonardo, CC.Ajmo, CT.Collier, LA.Willing, AE.Pennypacker, KR. Human umbilical cord blood cells directly suppress ischemic oligodendrocyte cell death. Journal of neuroscience research. 87(2): 333-41, 2009.
  • Hall, AA.Leonardo, CC.Collier, LA.Rowe, DD.Willing, AE.Pennypacker, KR. Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. Neuroscience. 164(2): 470-7, 2009.
  • Leonardo, CC.Hall, AA.Collier, LA.Gottschall, PE.Pennypacker, KR. Inhibition of gelatinase activity reduces neural injury in an ex vivo model of hypoxia-ischemia. Neuroscience. 160(4): 755-66, 2009.
  • Leonardo, CC.Hall, AA.Collier, LA.Ajmo, CT.Willing, AE.Pennypacker, KR. Human umbilical cord blood cell therapy blocks the morphological change and recruitment of CD11b-expressing, isolectin-binding proinflammatory cells after middle cerebral artery occlusion. Journal of neuroscience research. 88(6): 1213-22, 2010.
  • Hall, AA. Pennypacker, KR. Implications of immune system in stroke for novel therapeutic approaches Translational Stroke Research. 1(2): 85-95, 2010.
  • Cortes-Salva, M.Nguyen, BL.Cuevas, J.Pennypacker, KR.Antilla, JC. Copper-catalyzed guanidinylation of aryl iodides: the formation of N,N'-disubstituted guanidines. Organic letters. 12(6): 1316-9, 2010.
  • Ajmo, JM.Bailey, LA.Howell, MD.Cortez, LK.Pennypacker, KR.Mehta, HN.Morgan, D.Gordon, MN.Gottschall, PE. Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw. Journal of neurochemistry. 113(3): 784-95, 2010.
  • Leonardo, CC.Hall, AA.Collier, LA.Green, SM.Willing, AE.Pennypacker, KR. Administration of a Sigma Receptor Agonist Delays MCAO-Induced Neurodegeneration and White Matter Injury. Translational stroke research. 1(2): 135-145, 2010.
  • Rowe, DD.Leonardo, CC.Hall, AA.Shahaduzzaman, MD.Collier, LA.Willing, AE.Pennypacker, KR. Cord blood administration induces oligodendrocyte survival through alterations in gene expression. Brain research. 1366(): 172-88, 2010.
  • Das, M.Leonardo, CC.Rangooni, S.Mohapatra, SS.Mohapatra, S.Pennypacker, KR. Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats. Journal of neuroinflammation. 8(): 148, 2011.
  • Leonardo, CC. Pennypacker, KR. The splenic response to ischemic stroke: What have we learned from rodent models? Translational Stroke Research. 2(3): 328-38, 2011.
  • Seifert, HA. Leonardo, CC. Hall, AA. Rowe, DD. Collier, LA. Benkovic, SA. Willing, AE. Pennypacker, KR. The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling. Metabolic Brain Disease. [in press](): , 2012.
  • Rowe, DD.Leonardo, CC.Recio, JA.Collier, LA.Willing, AE.Pennypacker, KR. Human Umbilical Cord Blood Cells Protect Oligodendrocytes from Brain Ischemia through Akt Signal Transduction. The Journal of biological chemistry. 287(6): 4177-87, 2012.

    • Positions Held
  • Professor (Molecular Pharmacology & Physiology, College Of Medicine, University of South Florida 2007 - Present)
  • Associate Professor (Department of Pharmacology, College of Medicine, University of South Florida 2001 - 2007)


    • Memberships
  • American Society for Pharmacology and Experimetal Therapeutics (Member, 1999 - Present)
  • Society for Neuroscience (Member, 1983 - Present)


    • Awards/Honors
  • USF Biotechnology Award (University of South Florida - 2006)
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  • Grasso Award (Association of Medical Science Graduate Students - 2005)
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    Patents & Licensing
  • Method for the identification of drugs to treat stroke at delayed time points (Keith Pennypacker/Javier Cuevas - 2007)
  • Anti-spleen stroke therapy (Keith Pennypacker/Alison Willing/Martina Vendrame - 2007)
  • Effective treatment with sigma receptor agonists post-stroke (Javier Cuevas/Keith Pennypacker - 2006)


    • Grants
  • Anti-oxidant promoting cytokine LIF enhances neural cell survival during ischemia ($409,750.00, 09/01/2012-08/31/2014)
  • GLG-302 AS A NOVEL TREATMENT FOR STROKE ($100,000.00, 11/01/2011-10/31/2012)
  • SYNTHESIS AND SCREENING OF SIGMA LIGANDS FOR STROKE TREATMENT AT DELAYED TIME POINTS ($382,087.00, 07/01/2009-12/31/2011)
  • SYNTHESIS AND SCREENING OF SIGMA LIGANDS FOR STROKE TREATMENT AT DELAYED TIME POINTS ($382,087.00, 07/01/2009-06/30/2011)
  • EXPANDING THE THERAPEUTIC WINDOW FOR STROKE TREATMENT ($192,938.00, 07/01/2008-06/30/2011)
  • Cord blood is neuroprotective in a rat model of stroke ($151,000.00, 03/01/2006-02/28/2011)
  • EXPANDING THE THERAPEUTIC WINDOW FOR STROKE TREATMENT ($160,781.00, 07/01/2008-06/30/2010)
  • INVESTIGATING THE ROLE OF SIGMA RECEPTORS IN MODULATING THE INFLAMMATORY RESPONSE FOLLOWING STROKE ($21,770.00, 07/01/2007-06/30/2009)
  • INVESTIGATING THE ROLE OF SIGMA RECEPTORS IN MODULATING THE INFLAMMATORY RESPONSE FOLLOWING STROKE ($21,770.00, 07/01/2007-06/30/2009)
  • USE OF PIOGLITAZONE IN TREATING STROKE AT DELAYED TIME POINTS ($144,401.00, 02/13/2008-02/12/2009)
  • Splenic mechanisms of cord bood-induced brain repair ($88,194.00, 07/01/2007-12/31/2007)
  • NF-KB SIGNAL TRANSDUCTION IN BRAIN INJURY ($211,768.00, 09/30/2000-08/31/2004)
  • NF-KB SIGNAL TRANSDUCTION IN BRAIN INJURY ($211,935.00, 09/30/2000-08/31/2004)
  • NF-KB SIGNAL TRANSDUCTION IN BRAIN INJURY ($4,720.00, 09/30/2000-08/31/2004)
  • NF-KB SIGNAL TRANSDUCTION IN BRAIN INJURY ($212,097.00, 09/30/2000-08/31/2004)
  • NF-KB SIGNAL TRANSDUCTION IN BRAIN INJURY ($207,275.00, 09/30/2000-08/31/2004)
  • FOS-RELATED ANTIGEN-2EXPRESSION IN NEURONS SURVIVING ISCHEMIAY ($120,000.00, 07/01/2002-06/30/2004)
  • THE ROLE OF FRA-2 IN NEURONAL SURVIVAL USING A RAT MCA-O MODEL OF ISCHEMIA (FELLOWSHIP FOR TANYA BUTLER) ($70,000.00, 07/01/2001-06/30/2003)


    • Lectures
  • "Role of spleen in mediating inflammatory signaling after focal ischemia" American Society for Neurochemistry. MI, United States - 2009.
  • "Alternative targets for stroke treatment at delayed time points" Loma Linda University. CA, United States - 2009.
  • "Investigation of the multiple mechanisms of cord blood cell therapy in stroke" Indian Academy of Neurosciences. India - 2009.
  • "Balancing the Mission of Teaching, Research and Service in a College of Medicine" University of Central Florida College of Medicine. FL, United States - 2008.
  • "Mechanisms of neuroinflammation" Society for Neuroscience. CA, United States - 2007.
  • "Balancing the Mission of Teaching, Research and Service in an Academic Department" Ross Medical University. Dominica - 2007.

    • Profile last modified on 01/08/2013